14 July 2021 : Animal Research
Low Dose of Emodin Inhibits Hypercholesterolemia in a Rat Model of High Cholesterol
Jian-Hong Wu1ABCDEF, Chun-Fang Lv1ABDE, Xu-Jun Guo1CDEF, Huan Zhang2CF, Jinde Zhang1BD, Yangfeng Xu1BD, Jian Wang1AEG, Sheng-Yuan Liu3ACEFG*DOI: 10.12659/MSM.929346
Med Sci Monit 2021; 27:e929346
Figure 1 The acetylcholine concentration-response curves of the thoracic aortic rings are presented as decreases in the percentage of the steady-state precontraction tension obtained with 1 μM phenylephrine in (A) control, HCD, and SIM groups and (B) HCD, EH, EM, and EL groups. Data shown are the mean±SD, n=6–8. HCD – high-cholesterol diet group; SIM – simvastatin (10 mg/kg) treatment group; EH – high-dose emodin (100 mg/kg) treatment group; EM – medium-dose emodin (30 mg/kg) treatment group; EL – low-dose emodin (10 mg/kg) treatment group. ## P<0.01 vs control group; ** P<0.01 vs HCD group; NS – not significant.