14 July 2021 : Animal Research
Low Dose of Emodin Inhibits Hypercholesterolemia in a Rat Model of High Cholesterol
Jian-Hong Wu1ABCDEF, Chun-Fang Lv1ABDE, Xu-Jun Guo1CDEF, Huan Zhang2CF, Jinde Zhang1BD, Yangfeng Xu1BD, Jian Wang1AEG, Sheng-Yuan Liu3ACEFG*DOI: 10.12659/MSM.929346
Med Sci Monit 2021; 27:e929346
Figure 3 (A) Emodin reduced LDL-C concentration in serum and upregulated (B) hepatic LDLR mRNA expression and (C) LDLR protein expression. Hepatic LDLR mRNA and protein levels were determined by RT-qPCR and western blotting, respectively. Data are expressed as mean±SD, n=6–8. HCD – high-cholesterol diet group; SIM – simvastatin (10 mg/kg) treatment group; EH – high-dose emodin (100 mg/kg) treatment group; EM – medium-dose emodin (30 mg/kg) treatment group; EL – low-dose emodin (10 mg/kg) treatment group. # P<0.05, ## P<0.01, ### P<0.001 vs standard diet control group; * P<0.05, ** P<0.01, *** P<0.001 vs untreated HCD group.