Knockdown of Chitinase 3-Like-1 Inhibits Cell Proliferation, Promotes Apoptosis, and Enhances Effect of Anti-Programmed Death Ligand 1 (PD-L1) in Diffuse Large B Cell Lymphoma Cells

Xiao Yang; Dong Fang; Ming Li; Jiayi Chen; Yuanbo Cheng; Jianming Luo

doi:10.12659/MSM.929431

25 March 2021: Lab/In Vitro Research

Knockdown of Chitinase 3-Like-1 Inhibits Cell Proliferation, Promotes Apoptosis, and Enhances Effect of Anti-Programmed Death Ligand 1 (PD-L1) in Diffuse Large B Cell Lymphoma Cells

Xiao Yang ^1AC* , Dong Fang ^2B* , Ming Li ^1F , Jiayi Chen ^1B , Yuanbo Cheng ^1F , Jianming Luo ^1DE*

DOI: 10.12659/MSM.929431

Med Sci Monit 2021; 27:e929431

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Figure 1 CHI3L1 is highly expressed in SU-DHL-4. (A) Western blot analysis of CHI3L1 protein expression in various DLBCL cell lines. (B) RT-PCR analysis of CHI3L1 protein expression in various DLBCL cell lines. Data are presented as mean±SD. Results shown here are the representative of 3 independent experiments. *** p<0.005 vs GM12878.

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Knockdown of Chitinase 3-Like-1 Inhibits Cell Proliferation, Promotes Apoptosis, and Enhances Effect of Anti-Programmed Death Ligand 1 (PD-L1) in Diffuse Large B Cell Lymphoma Cells

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