25 March 2021: Lab/In Vitro Research
Knockdown of Chitinase 3-Like-1 Inhibits Cell Proliferation, Promotes Apoptosis, and Enhances Effect of Anti-Programmed Death Ligand 1 (PD-L1) in Diffuse Large B Cell Lymphoma Cells
Xiao Yang 1AC* , Dong Fang 2B* , Ming Li 1F , Jiayi Chen 1B , Yuanbo Cheng 1F , Jianming Luo 1DE*DOI: 10.12659/MSM.929431
Med Sci Monit 2021; 27:e929431
Figure 5 knockdown of CHI3L1 promotes the effect of anti-PD-L1 antibody and cell proliferation and cell cycle arrest in vivo. (A) Western blot analysis of bax, cleaved caspase3, and cleaved PARP expression in vivo. (B) Western blot analysis of p53 and survivin expression in vivo. Data are presented as mean±SD. Results shown here are representative of 3 independent experiments. * p<0.05, ** p<0.01, *** p<0.005 vs Control; # p<0.05, ## p<0.01, ### p<0.005 vs shRNA-CHI3L1-1; @ p<0.05, @@ p<0.01 vs Anti-PD-L1.