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16 July 2021: Lab/In Vitro Research

lncRNA MEG3 Downregulation Relieves Intracerebral Hemorrhage by Inhibiting Oxidative Stress and Inflammation in an miR-181b-Dependent Manner

Bo Xie 1ABCDEFG , Mingliang Qiao 1BCD , Jialong Xuan 2BCEF*

DOI: 10.12659/MSM.929435

Med Sci Monit 2021; 27:e929435

Figure 4 Effect of lncRNA MEG3-shRNA or miR-181b inhibitor on miR-181b expression in ICH rats brain tissues. After ICH stimulation for 1 h, control-shRNA, MEG3-shRNA, inhibitor control, or miR-181b inhibitor were injected into ICH rats. Three days after ICH induction, (A) qRT-PCR analysis of MEG3-shRNA on lncRNA MEG3 expression; (B) The inhibitory effect of miR-181b inhibitor on miR-181b levels was detected using qRT-PCR; (C) qRT-PCR assay was performed to measure miR-181b level in brain tissues of ICH rats after MEG3-shRNA + miR-181b inhibitor or MEG3-shRNA +inhibitor control treatment. ** P<0.01 vs ICH+control-shRNA; ## P<0.01 vs ICH+inhibitor control; && P<0.01 vs ICH+MEG3-shRNA+inhibitor control.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750