16 July 2021>: Lab/In Vitro Research
lncRNA MEG3 Downregulation Relieves Intracerebral Hemorrhage by Inhibiting Oxidative Stress and Inflammation in an miR-181b-Dependent MannerBo Xie 1ABCDEFG , Mingliang Qiao 1BCD , Jialong Xuan 2BCEF*
Med Sci Monit 2021; 27:e929435
Figure 5 Effects of lncRNA MEG3-shRNA on neurological damage in ICH rats. After ICH induction, ICH rats were treated with control-shRNA, lncRNA MEG3-shRNA, inhibitor control, or miR-181b inhibitor. (A) At 1 hour following ICH or sham operation, the neurobehavioral scores of rats were measured by neurological severity score method. (B) The mNSS test was applied to assess neurobehavioral scores at 3 days after ICH or sham operation in different groups. (C) Three days after ICH induction, brain water contents were assessed using the wet/dry method in different groups. ** P<0.01 vs Sham; #, ## P<0.05, 0.01 vs ICH+control-shRNA; &, && P<0.05, 0.01 vs ICH+MEG3-shRNA+inhibitor control.