16 July 2021: Lab/In Vitro Research
lncRNA MEG3 Downregulation Relieves Intracerebral Hemorrhage by Inhibiting Oxidative Stress and Inflammation in an miR-181b-Dependent Manner
Bo Xie 1ABCDEFG , Mingliang Qiao 1BCD , Jialong Xuan 2BCEF*DOI: 10.12659/MSM.929435
Med Sci Monit 2021; 27:e929435
Figure 7 miR-181b inhibitor reversed the effects of lncRNA MEG3-shRNA on inflammatory response and oxidative stress in ICH rats. Rats were divided into 6 groups: Sham, ICH, ICH+control-shRNA, ICH+lncRNA MEG3-shRNA, ICH+lncRNA MEG3-shRNA+inhibitor control, and ICH+lncRNA MEG3-shRNA+miR-181b inhibitor. Three days after ICH induction, levels of TNF-α (A, B) and IL-1β (C, D) in the rat CSF and serum of all rats were measured using ELISA. MDA (E) and SOD activity (F) in the serum of rats were determined. ** P<0.01 vs Sham; ## P<0.01 vs ICH+control-shRNA; &, && P<0.05, 0.01 vs ICH+MEG3-shRNA+inhibitor control.