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16 July 2021: Lab/In Vitro Research

lncRNA MEG3 Downregulation Relieves Intracerebral Hemorrhage by Inhibiting Oxidative Stress and Inflammation in an miR-181b-Dependent Manner

Bo Xie 1ABCDEFG , Mingliang Qiao 1BCD , Jialong Xuan 2BCEF*

DOI: 10.12659/MSM.929435

Med Sci Monit 2021; 27:e929435

Figure 8 (A, B) Effect of lncRNA MEG3 on PI3K/AKT pathway in ICH rats by targeting miR-181b. One hour after ICH induction, control-shRNA, lncRNA MEG3-shRNA, inhibitor control, or miR-181b inhibitor were injected into rats. Three days after ICH induction, the protein levels of p-AKT and AKT were assessed using western blotting in different groups. The ratio of p-AKT/AKT was calculated and presented. ** P<0.01 vs sham; ## P<0.01 vs ICH+control-shRNA; && P<0.01 vs ICH+MEG3-shRNA+inhibitor control.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750