Anti-Psoriatic Effects of Middle Fragment of Chlamydial Plasmid-Encoded Protein pGP3 in an Imiquimod-Induced Psoriasis Mouse Model

Yiming Zhang; Miaomiao Ma; Jun Li; Yingye Wu; Lu Xue; Rongrong Zhao; Lu Wang; Shuping Hou; Huiping Wang

doi:10.12659/MSM.929781

05 June 2021 : Animal Research

Anti-Psoriatic Effects of Middle Fragment of Chlamydial Plasmid-Encoded Protein pGP3 in an Imiquimod-Induced Psoriasis Mouse Model

Yiming Zhang^1A, Miaomiao Ma^2A, Jun Li^3D, Yingye Wu^2C, Lu Xue^2C, Rongrong Zhao^2B, Lu Wang^2E, Shuping Hou^2G, Huiping Wang^2G*

DOI: 10.12659/MSM.929781

Med Sci Monit 2021; 27:e929781

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Figure 5 Histological examinations of the skin sections stained with hematoxylin-eosin (Magnification: 200×). (A) Normal mice. (B) The skin sections of the imiquimod (IMQ) group exhibited epidermal thickening, hyperkeratosis, parakeratosis, and inflammation in the dermis. (C, D) The hyperkeratosis and acanthosis in the pGP3 (IM-pGP3) and pGP3M (IM-pGP3M) intramuscular injection groups were milder than that in the IMQ group and (E) the phosphate-buffered saline intramuscular injection group.

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Anti-Psoriatic Effects of Middle Fragment of Chlamydial Plasmid-Encoded Protein pGP3 in an Imiquimod-Induced Psoriasis Mouse Model

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