21 June 2021 : Laboratory Research
Salvianolic Acid A Protects H9C2 Cardiomyocytes from Doxorubicin-Induced Damage by Inhibiting NFKB1 Expression Thereby Downregulating Long-Noncoding RNA (lncRNA) Plasmacytoma Variant Translocation 1 (PVT1)
Yumeng Wu1ABF, Wei Xiu2CD, Yubo Wu1AEF*DOI: 10.12659/MSM.929824
Med Sci Monit 2021; 27:e929824
Figure 3 The effect of salvianolic acid A (SalA) on doxorubicin (Dox)-activated nuclear factor-κB (NF-κB) signaling and nuclear factor kappa B subunit 1 (NFKB1) expression in H9C2 cells. (A) The expression of proteins involved in the NF-κB pathway in H9C2 cells was detected by western blot. (B) The mRNA expression of NFKB1 in H9C2 cells that were subjected to different treatments. (C) The protein expression of cytoplasmic and nuclear p50 in H9C2 cells. *** P<0.001; # P<0.05; ## P<0.01; ### P<0.001.