Salvianolic Acid A Protects H9C2 Cardiomyocytes from Doxorubicin-Induced Damage by Inhibiting NFKB1 Expression Thereby Downregulating Long-Noncoding RNA (lncRNA) Plasmacytoma Variant Translocation 1 (PVT1)

Yumeng Wu; Wei Xiu; Yubo Wu

doi:10.12659/MSM.929824

21 June 2021 : Laboratory Research

Salvianolic Acid A Protects H9C2 Cardiomyocytes from Doxorubicin-Induced Damage by Inhibiting NFKB1 Expression Thereby Downregulating Long-Noncoding RNA (lncRNA) Plasmacytoma Variant Translocation 1 (PVT1)

Yumeng Wu^1ABF, Wei Xiu^2CD, Yubo Wu^1AEF*

DOI: 10.12659/MSM.929824

Med Sci Monit 2021; 27:e929824

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Figure 5 The effect of nuclear factor kappa B subunit 1 (NFKB1) overexpression on salvianolic acid A (SalA)-inhibited apoptosis in H9C2 cells. (A) The expression of plasmacytoma variant translocation 1 (PVT1) in H9C2 cells. (B) Cell viability of H9C2 cells that were subjected to indicated treatments. (C, D) Representative images (×200) and quantitative analysis for TUNEL staining in H9C2 cells. (E) The expression of proteins related to apoptosis in H9C2 cells was detected by western blot. *** P<0.001; ### P<0.001. @ P<0.05; @@ P<0.01; @@@ P<0.001.

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Salvianolic Acid A Protects H9C2 Cardiomyocytes from Doxorubicin-Induced Damage by Inhibiting NFKB1 Expression Thereby Downregulating Long-Noncoding RNA (lncRNA) Plasmacytoma Variant Translocation 1 (PVT1)

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