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15 March 2021: Lab/In Vitro Research

Long Noncoding RNA TCONS_00068220 Promotes Breast Cancer Progression by Regulating Epithelial-Mesenchymal Transition Marker E-Cadherin

Xiao Liu 12ABEF , Xingsong Tian 1ACDG

DOI: 10.12659/MSM.929832

Med Sci Monit 2021; 27:e929832

Figure 2 TCONS_00068220 modulates aggressive behaviors in breast cancer cells. TCONS_00068220 was overexpressed in the MCF-7 cell line and silenced in the MDA-MB-231 cell line via lentiviral vector-mediated transduction. (A) Verification of the efficiency of TCONS_00068220 overexpression or knockdown via qRT-PCR. (B) Cell proliferation was evaluated using a CCK8 assay after TCONS_00068220 overexpression or silencing. A transwell assay showed the effects of TCONS_00068220 expression alterations on cell migration (C) and invasion (D). * P<0.05 and ** P<0.01 vs control group.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750