Human Umbilical Cord Mesenchymal Stem Cell Therapy Mitigates Interstitial Cystitis by Inhibiting Mast Cells

Yuancheng Xu; Fei Yang; Juncong Xie; Wenbiao Li; Bolong Liu; Jialiang Chen; Honglu Ding; Jiarong Cai

doi:10.12659/MSM.930001

06 August 2021 : Animal Research

Human Umbilical Cord Mesenchymal Stem Cell Therapy Mitigates Interstitial Cystitis by Inhibiting Mast Cells

Yuancheng Xu^1ABDEF*, Fei Yang^1BC, Juncong Xie^1BC, Wenbiao Li^1BC, Bolong Liu^1BD, Jialiang Chen^1BC, Honglu Ding^1BC, Jiarong Cai^1EF

DOI: 10.12659/MSM.930001

Med Sci Monit 2021; 27:e930001

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Figure 5 β-Hexosaminidase secretion was evaluated by ELISA. (A) β-Hexosaminidase assay: the concentration of β-hex released from the sensitized RBL-2H3 cells was significantly higher than that of normal RBL-2H3 cells. ** P<0.01 vs sham group. (B, C) Histamine and 5-hydroxytryptamine (5-HT) levels in the C48+MSC group were significantly lower than in the C48 group. ** P<0.01 vs sham group; ## P<0.01 vs C48 group.

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Human Umbilical Cord Mesenchymal Stem Cell Therapy Mitigates Interstitial Cystitis by Inhibiting Mast Cells

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