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14 June 2021: Lab/In Vitro Research

Helenalin Facilitates Reactive Oxygen Species-Mediated Apoptosis and Cell Cycle Arrest by Targeting Thioredoxin Reductase-1 in Human Prostate Cancer Cells

Mei Yang 1A , Weihua Zhang 2B , Xiuxiu Yu 3C , Feng Wang 3D , Yeping Li 3E , Yan Zhang 3F , Yu Yang 3AG*

DOI: 10.12659/MSM.930083

Med Sci Monit 2021; 27:e930083

Figure 1 Helenalin represses the viability of human prostate cancer cells in a concentration-dependent manner. (A) Chemical structure of helenalin. (B–E) The effect of different doses of helenalin on the cellular viability for (B) human prostate RWPE1 cells, human AR-negative prostate cancer, (C) DU145, and (D) PC-3 cells, and (E) human neuroendocrine prostate cancer NCI-H660 cells. Ns – no statistical significance; ** P<0.01; **** P<0.0001.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750