14 June 2021 : Laboratory Research
Helenalin Facilitates Reactive Oxygen Species-Mediated Apoptosis and Cell Cycle Arrest by Targeting Thioredoxin Reductase-1 in Human Prostate Cancer Cells
Mei Yang1A, Weihua Zhang2B, Xiuxiu Yu3C, Feng Wang3D, Yeping Li3E, Yan Zhang3F, Yu Yang3AG*DOI: 10.12659/MSM.930083
Med Sci Monit 2021; 27:e930083
Figure 1 Helenalin represses the viability of human prostate cancer cells in a concentration-dependent manner. (A) Chemical structure of helenalin. (B–E) The effect of different doses of helenalin on the cellular viability for (B) human prostate RWPE1 cells, human AR-negative prostate cancer, (C) DU145, and (D) PC-3 cells, and (E) human neuroendocrine prostate cancer NCI-H660 cells. Ns – no statistical significance; ** P<0.01; **** P<0.0001.