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14 June 2021: Lab/In Vitro Research

Helenalin Facilitates Reactive Oxygen Species-Mediated Apoptosis and Cell Cycle Arrest by Targeting Thioredoxin Reductase-1 in Human Prostate Cancer Cells

Mei Yang 1A , Weihua Zhang 2B , Xiuxiu Yu 3C , Feng Wang 3D , Yeping Li 3E , Yan Zhang 3F , Yu Yang 3AG*

DOI: 10.12659/MSM.930083

Med Sci Monit 2021; 27:e930083

Figure 5 Helenalin exposure promotes ROS generation by suppression of TrxR1 in prostate carcinoma cells. (A, B) The ROS levels were examined for 2 prostate carcinoma cells exposed to si-TrxR1, TrxR1 plasmid, and/or helenalin by DCFH-DA staining. Bar=50 μM.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750