Helenalin Facilitates Reactive Oxygen Species-Mediated Apoptosis and Cell Cycle Arrest by Targeting Thioredoxin Reductase-1 in Human Prostate Cancer Cells

Mei Yang; Weihua Zhang; Xiuxiu Yu; Feng Wang; Yeping Li; Yan Zhang; Yu Yang

doi:10.12659/MSM.930083

14 June 2021: Lab/In Vitro Research

Helenalin Facilitates Reactive Oxygen Species-Mediated Apoptosis and Cell Cycle Arrest by Targeting Thioredoxin Reductase-1 in Human Prostate Cancer Cells

Mei Yang ^1A , Weihua Zhang ^2B , Xiuxiu Yu ^3C , Feng Wang ^3D , Yeping Li ^3E , Yan Zhang ^3F , Yu Yang ^3AG*

DOI: 10.12659/MSM.930083

Med Sci Monit 2021; 27:e930083

Authors information Article notes Copyright and License information

Background Material and Methods Results Discussion Conclusions References

View HTML version

Figure 5 Helenalin exposure promotes ROS generation by suppression of TrxR1 in prostate carcinoma cells. (A, B) The ROS levels were examined for 2 prostate carcinoma cells exposed to si-TrxR1, TrxR1 plasmid, and/or helenalin by DCFH-DA staining. Bar=50 μM.

Back to the Article

Helenalin Facilitates Reactive Oxygen Species-Mediated Apoptosis and Cell Cycle Arrest by Targeting Thioredoxin Reductase-1 in Human Prostate Cancer Cells

Your Privacy