Helenalin Facilitates Reactive Oxygen Species-Mediated Apoptosis and Cell Cycle Arrest by Targeting Thioredoxin Reductase-1 in Human Prostate Cancer Cells

Mei Yang; Weihua Zhang; Xiuxiu Yu; Feng Wang; Yeping Li; Yan Zhang; Yu Yang

doi:10.12659/MSM.930083

14 June 2021 : Laboratory Research

Helenalin Facilitates Reactive Oxygen Species-Mediated Apoptosis and Cell Cycle Arrest by Targeting Thioredoxin Reductase-1 in Human Prostate Cancer Cells

Mei Yang^1A, Weihua Zhang^2B, Xiuxiu Yu^3C, Feng Wang^3D, Yeping Li^3E, Yan Zhang^3F, Yu Yang^3AG*

DOI: 10.12659/MSM.930083

Med Sci Monit 2021; 27:e930083

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Figure 5 Helenalin exposure promotes ROS generation by suppression of TrxR1 in prostate carcinoma cells. (A, B) The ROS levels were examined for 2 prostate carcinoma cells exposed to si-TrxR1, TrxR1 plasmid, and/or helenalin by DCFH-DA staining. Bar=50 μM.

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Helenalin Facilitates Reactive Oxygen Species-Mediated Apoptosis and Cell Cycle Arrest by Targeting Thioredoxin Reductase-1 in Human Prostate Cancer Cells

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