14 June 2021 : Laboratory Research
Helenalin Facilitates Reactive Oxygen Species-Mediated Apoptosis and Cell Cycle Arrest by Targeting Thioredoxin Reductase-1 in Human Prostate Cancer Cells
Mei Yang1A, Weihua Zhang2B, Xiuxiu Yu3C, Feng Wang3D, Yeping Li3E, Yan Zhang3F, Yu Yang3AG*DOI: 10.12659/MSM.930083
Med Sci Monit 2021; 27:e930083
Figure 7 Helenalin suppresses migration and invasion by TrxR1 expression in prostate carcinoma cells. (A–D) Migration distance was detected in (A, B) DU145 and (C, D) PC-3 cells treated with TrxR1 plasmid and/or helenalin by wound healing assay. (E–G) The number of invasive DU145 and PC-3 cells was assessed following treatment with TrxR1 plasmid and/or helenalin by transwell assay. * P<0.05; ** P<0.01, *** P<0.001; **** P<0.0001.