Protective Effects of Bone Marrow Mesenchymal Stem Cells (BMMSCS) Combined with Normothermic Machine Perfusion on Liver Grafts Donated After Circulatory Death via Reducing the Ferroptosis of Hepatocytes

Dong Sun; Liu Yang; Weiping Zheng; Huan Cao; Longlong Wu; Hongli Song

doi:10.12659/MSM.930258

11 June 2021 : Animal Research

Protective Effects of Bone Marrow Mesenchymal Stem Cells (BMMSCS) Combined with Normothermic Machine Perfusion on Liver Grafts Donated After Circulatory Death via Reducing the Ferroptosis of Hepatocytes

Dong Sun^1BCDEF, Liu Yang^1BCDEF, Weiping Zheng^23CE, Huan Cao^14BD, Longlong Wu^5DF, Hongli Song^26AG*

DOI: 10.12659/MSM.930258

Med Sci Monit 2021; 27:e930258

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Figure 3 Quality of DCD donor livers ameliorated by BMMSCs combined with NMP. (A) Gross appearance of DCD donor livers; (B) Histopathological change of DCD donor livers. I: warm ischemia at 30 min; II: 6 h in the SCS group; III: 6 h in the P group; IV: 6 h in the BP group. BMMSCs – bone marrow mesenchymal stem cells; P – NMP; BP – NMP combined with BMMSCs; NMP – normothermic machine perfusion; SCS – static cold storage.

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Protective Effects of Bone Marrow Mesenchymal Stem Cells (BMMSCS) Combined with Normothermic Machine Perfusion on Liver Grafts Donated After Circulatory Death via Reducing the Ferroptosis of Hepatocytes

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