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19 May 2021: Animal Study

Pretreatment with Propofol Reduces Pulmonary Injury in a Pig Model of Intestinal Ischemia-Reperfusion via Suppressing the High-Mobility Group Box 1 Protein (HMGB1)/Toll-Like Receptor 4 (TLR4)/Protein Kinase R (PKR) Signaling Pathway

Wen-yu Bian 1BC* , Ya-ping Chen 2DF* , Bo Xu 3AE* , Jun Tang 4AE*

DOI: 10.12659/MSM.930478

Med Sci Monit 2021; 27:e930478

Figure 4 Histopathologic sections of the lung tissue. The sections of a sham IIR pig (A1, A2), a saline-pretreated IIR pig (B1, B2), and a propofol-pretreated IIR pig (C1, C2). The lung tissue of the pig with IIR shows severe damage, with alveolar collapse, a widened alveolar septum, small blood vessel bleeding, and neutrophil infiltration. Propofol significantly attenuated the changes induced by IIR. A1-C1 are displayed with 100 times magnification, while A2-C2 are displayed with 200 times magnification. The lung histopathologic score is displayed in panel D. ** P<0.01 compared with the sham group, # P<0.05 compared with the IIR+NS group. a, ×100; b, ×200. IIR – intestinal ischemia-reperfusion; NS – normal saline; P – propofol.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750