19 May 2021 : Animal Research
Pretreatment with Propofol Reduces Pulmonary Injury in a Pig Model of Intestinal Ischemia-Reperfusion via Suppressing the High-Mobility Group Box 1 Protein (HMGB1)/Toll-Like Receptor 4 (TLR4)/Protein Kinase R (PKR) Signaling Pathway
Wen-yu Bian1BC, Ya-ping Chen2DF, Bo Xu3AE*, Jun Tang4AEDOI: 10.12659/MSM.930478
Med Sci Monit 2021; 27:e930478
Figure 5 (A, B) Pulmonary and plasma myeloperoxidase (MPO) activity. Propofol at 10 ml/kg or the same volume of saline was intravenously injected into pigs with a computerized infusion pump via the femoral vein 10 min before the start of reperfusion. Lung tissues and blood were collected from pigs at 4 h after reperfusion. Data are expressed as the mean±SD, n=8. ** P<0.01 compared with the sham group, # P<0.05 compared with the IIR+NS group. IIR – intestinal ischemia-reperfusion; NS – normal saline; P – propofol.