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19 May 2021: Animal Study

Pretreatment with Propofol Reduces Pulmonary Injury in a Pig Model of Intestinal Ischemia-Reperfusion via Suppressing the High-Mobility Group Box 1 Protein (HMGB1)/Toll-Like Receptor 4 (TLR4)/Protein Kinase R (PKR) Signaling Pathway

Wen-yu Bian 1BC* , Ya-ping Chen 2DF* , Bo Xu 3AE* , Jun Tang 4AE*

DOI: 10.12659/MSM.930478

Med Sci Monit 2021; 27:e930478

Figure 6 (A–D) Pulmonary and plasma superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels. Propofol at 10 ml/kg or the same volume of saline was intravenously injected into pigs with a computerized infusion pump via the femoral vein 10 min before the start of reperfusion. Lung tissues and blood were collected from pigs at 4 h after reperfusion. Data are expressed as the mean±SD, n=8. ** P<0.01 compared with the sham group, # P<0.05 compared with the IIR+NS group. IIR – intestinal ischemia-reperfusion; NS – normal saline; P – propofol.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750