Pretreatment with Propofol Reduces Pulmonary Injury in a Pig Model of Intestinal Ischemia-Reperfusion via Suppressing the High-Mobility Group Box 1 Protein (HMGB1)/Toll-Like Receptor 4 (TLR4)/Protein Kinase R (PKR) Signaling Pathway

Wen-yu Bian; Ya-ping Chen; Bo Xu; Jun Tang

doi:10.12659/MSM.930478

19 May 2021 : Animal Research

Pretreatment with Propofol Reduces Pulmonary Injury in a Pig Model of Intestinal Ischemia-Reperfusion via Suppressing the High-Mobility Group Box 1 Protein (HMGB1)/Toll-Like Receptor 4 (TLR4)/Protein Kinase R (PKR) Signaling Pathway

Wen-yu Bian^1BC, Ya-ping Chen^2DF, Bo Xu^3AE*, Jun Tang^4AE

DOI: 10.12659/MSM.930478

Med Sci Monit 2021; 27:e930478

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Figure 7 (A–D) Protein expression level of HMGB1/TLR4/PKR by western blot, IIR+NS, and IIR+P groups. Data are expressed as the mean±SD (n=8). ** P<0.01 compared with the sham group. # P<0.05 compared with IIR+NS group. IIR – intestinal ischemia-reperfusion; NS – normal saline; P – propofol.

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Pretreatment with Propofol Reduces Pulmonary Injury in a Pig Model of Intestinal Ischemia-Reperfusion via Suppressing the High-Mobility Group Box 1 Protein (HMGB1)/Toll-Like Receptor 4 (TLR4)/Protein Kinase R (PKR) Signaling Pathway

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