miR-1283 Contributes to Endoplasmic Reticulum Stress in the Development of Hypertension Through the Activating Transcription Factor-4 (ATF4)/C/EBP-Homologous Protein (CHOP) Signaling Pathway

Weihao Chen; Tianhao Liu; Qiuer Liang; Xudong Chen; Wencong Tao; Meixia Fang; Ya Xiao; Liguo Chen

doi:10.12659/MSM.930552

29 April 2021 : Animal Research

miR-1283 Contributes to Endoplasmic Reticulum Stress in the Development of Hypertension Through the Activating Transcription Factor-4 (ATF4)/C/EBP-Homologous Protein (CHOP) Signaling Pathway

Weihao Chen^1ABC, Tianhao Liu^1EF*, Qiuer Liang^1F, Xudong Chen^1BC, Wencong Tao^1B, Meixia Fang^1AE, Ya Xiao^1AE, Liguo Chen^1AEG

DOI: 10.12659/MSM.930552

Med Sci Monit 2021; 27:e930552

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Figure 10 The proteins expression of endoplasmic reticulum stress and apoptosis-related genes in of activating transcription factor 4 (ATF4) knockout mice induced by high salt. (A–G) ATF4, C/EBP-homologous protein (CHOP), BCL-2, BCL-X, BH3-interacting domain death agonist (BID), Bcl-2-like protein 11 (BIM), caspase-3 protein expression. (H) Western blotting of indicated proteins. WT-NS – wild-type+normal salt group; WT-HS – wild-type+high salt group; KO-NS – ATF4+/−+normal salt group; KO-HS – ATF4+/−+high salt group. * P<0.05.

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miR-1283 Contributes to Endoplasmic Reticulum Stress in the Development of Hypertension Through the Activating Transcription Factor-4 (ATF4)/C/EBP-Homologous Protein (CHOP) Signaling Pathway

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