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28 January 2021: Animal Study

Bluetongue Viruses Act as Novel Oncolytic Viruses to Effectively Inhibit Human Renal Cancer Cell Growth and

Haozhou Wang ABCE , Liming Song DEF , Xin Zhang BCF , Xiaodong Zhang AF* , Xiaoguang Zhou ABG*

DOI: 10.12659/MSM.930634

Med Sci Monit 2021; 27:e930634

Figure 3 BTVs exert antitumor effects in a renal cancer OS-RC-2 xenograft mouse model. (A) Representative tumor sections from treated mice were harvested after treatment and analyzed by H&E (×40 and×100), cell proliferation (Ki67 ×400), apoptosis (TUNEL ×1000), or angiogenesis (VEGF ×200), by immunohistochemistry. The H&E staining shows that the tumor tissue had disintegrated into smaller components. T – tumor tissue, S – tumor stroma. Sinusoid-like blood vessels were occlusive, degenerated, or absent entirely. The VEGF staining showed less immunoreactivity in BTV-treated tumors than in control groups. (B) Tumor volume (mm3) was measured and the data are presented as mean±SD. Body weight was monitored continuously, and the data shown represent the mean±SD. (C) Quantification of mitotic index (left), and apoptosis (right). Labeled cells were counted in an average of 6 high-power fields. Data represent means±SEM. (D) H&E staining also revealed apoptotic-type cells, such as condensed nuclei and cytoplasm (arrow), in BTV-treated tumors.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750