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05 September 2021: Animal Study

Live Combined and Alleviate Liver Inflammation, Improve Intestinal Barrier Function, and Modulate Gut Microbiota in Mice with Non-Alcoholic Fatty Liver Disease

Jie Jiang 1BCDE , Jie Xiong 1ACEFG* , Jianbo Ni 2CDE , Congying Chen 2CD , Kezhou Wang 3C

DOI: 10.12659/MSM.931143

Med Sci Monit 2021; 27:e931143

Figure 2 Effect of LCBE on serum lipid metabolism, ALT, and AST levels in mice fed a high-fat diet. (A) Serum triglyceride; (B) serum total cholesterol; (C) serum low-density lipoprotein cholesterol; (D) serum high-density lipoprotein cholesterol; (E) activity of serum ALT; (F) activity of serum AST; (G) histopathology images of liver tissues ((I) H&E, 200× magnification; Oil Red O, 200× magnification); and (H) protein expression levels of PPAR-α and CPT-1 in the liver. GAPDH was used in the loading chow. The data are expressed as means±SD. * P<0.05, ** P<0.01, *** P<0.001 vs Chow, # P<0.05, ## P<0.01, ### P<0.001 vs HFD.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750