09 August 2021: Animal Study
Comparison of the Effects of Intraperitoneal Injection with Carbon Tetrachloride on Acute Liver Toxicity in Male and Female Kunming Mice
Huan Yang 12ABE , San-Qiang Li 12CDG* , Shan-Long Wang 12B , Ying Song 12BCDEF , Wei-Gang Cheng 12BF , Yong Wang 12F , Bing-Bing Zhang 12BF , Dong-Mei Wang 12D , Yun-Long Wang 3DFDOI: 10.12659/MSM.931427
Med Sci Monit 2021; 27:e931427
Figure 1 (A) Serum aspartate aminotransferase (AST), (B) alanine aminotransferase (ALT) levels, and (C) AST/ALT ratio in mice at 24 h after intraperitoneal injection of carbon tetrachloride (CCl4). Male or female mice that were fed normally formed the normal group, mice that were treated with normal feeding plus olive oil intake by intraperitoneal injection formed the normal control group, and the CCl4 group comprised normal feeding plus 0.1% CCl4, which was diluted with olive oil intake (0.1 ml per 10 g body weight) by intraperitoneal injection. All data are presented as the mean±standard deviation (SD). ** P<0.01: there was a significant difference between the female group and the male group. ## P<0.01: there was a significant difference between the female CCl4 group and the normal group or the normal control group. & P<0.05: there was a significant difference between the male CCl4 group and the normal group or the normal control group. Experiments were repeated in triplicate.