26 September 2021 : Animal Research
Different Anesthetic Drugs Mediate Changes in Neuroplasticity During Cognitive Impairment in Sleep-Deprived Rats via Different Factors
Mengxi Shen12ABCDEF, Naqi Lian12BCE, Chengcheng Song12DE, Chao Qin12BD, Yang Yu12AE*, Yonghao Yu12ABEDOI: 10.12659/MSM.932422
Med Sci Monit 2021; 27:e932422
Figure 10 Change in hippocampal dendritic spines after administration of Tau modification agonistIn the DG region, dendritic spines’ density was decreased in the SD and Prop groups compared with before. The dendritic spines in DG and CA 1 regions in the SD+Prop group were denser than those in the Control group, suggesting that the effects of sleep deprivation and intravenous anesthesia on cognitive function can eventually change synaptic plasticity, thus affecting long-term cognitive function. Propofol infusion had a definite reversal effect on cognitive dysfunction caused by sleep deprivation.