Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

26 September 2021: Animal Study

Different Anesthetic Drugs Mediate Changes in Neuroplasticity During Cognitive Impairment in Sleep-Deprived Rats via Different Factors

Mengxi Shen 12ABCDEF* , Naqi Lian 12BCE* , Chengcheng Song 12DE , Chao Qin 12BD , Yang Yu 12AE* , Yonghao Yu 12ABE*

DOI: 10.12659/MSM.932422

Med Sci Monit 2021; 27:e932422

Figure 5 Expression of SIK3, PSD-95, and proteins associated with tau modification before administration of inhibitor or agonist in rats(A) Compared with the Control group, the expression level of tau protein in the hippocampus in the SD group was upregulated. Tau protein phosphorylation’s expression level was significantly upregulated, with a decreased acetylation level and an increased phosphorylation/acetylation ratio. The Sevo group exhibited increased SIK3 expression, while other changes were similar to those in the SD group. There was no statistically significant difference between the 2 groups. Compared with the SD group, the expression of SIK3 in the SD+Sevo group was upregulated. The levels of tau and its phosphorylation were increased, and the phosphorylation/acetylation ratio was increased, with statistical significance. In the change of PSD-95, the expression of the SD+Sevo group was significantly reduced. Simultaneously, the SD group and Sevo group also showed a certain degree of expression decline, and the difference was statistically significant. (* P<0.05, Control vs SD, Control vs Sevo, SD vs SD+Sevo). (B) Compared with the Con group, the expressions of SIK3, tau, p-tau were slightly increased, and ace-tau expression was slightly decreased in the SD group. The expression levels of related proteins in the Prop group were unchanged compared with the Con group. SIK3, tau, and p-tau were expressed at reduced levels. The phosphorylation/acetylation ratio was decreased in the SD+Prop group compared with the SD group. Their expression levels were similar to those in the Con group. For PSD-95 expression, SD reduced its expression, and there were no significant differences in PSD-95 expression between Con, Prop, and SD+Prop groups. (* p<0.05, Con vs SD, Con vs Prop, SD vs SD+Prop).

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750