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26 September 2021: Animal Study

Different Anesthetic Drugs Mediate Changes in Neuroplasticity During Cognitive Impairment in Sleep-Deprived Rats via Different Factors

Mengxi Shen 12ABCDEF* , Naqi Lian 12BCE* , Chengcheng Song 12DE , Chao Qin 12BD , Yang Yu 12AE* , Yonghao Yu 12ABE*

DOI: 10.12659/MSM.932422

Med Sci Monit 2021; 27:e932422

Figure 9 Change in hippocampal dendritic spines after administration of the SIK3 inhibitor YKL-05-099The changes of bilateral hippocampal neural plasticity in each group were observed by Golgi staining. In the DG region, there was a statistically significant increase in dendritic spine density in the SD and Sevo groups compared to before inhibitor administration. The density of dendritic spines in DG and CA 1 regions in the SD+Sevo group was slightly decreased, suggesting that the effects of sleep deprivation and inhalation anesthesia on cognitive function ultimately changed synaptic plasticity and thus affected long-term cognitive function.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750