26 September 2021 : Animal Research
Different Anesthetic Drugs Mediate Changes in Neuroplasticity During Cognitive Impairment in Sleep-Deprived Rats via Different Factors
Mengxi Shen12ABCDEF, Naqi Lian12BCE, Chengcheng Song12DE, Chao Qin12BD, Yang Yu12AE*, Yonghao Yu12ABEDOI: 10.12659/MSM.932422
Med Sci Monit 2021; 27:e932422
Figure 9 Change in hippocampal dendritic spines after administration of the SIK3 inhibitor YKL-05-099The changes of bilateral hippocampal neural plasticity in each group were observed by Golgi staining. In the DG region, there was a statistically significant increase in dendritic spine density in the SD and Sevo groups compared to before inhibitor administration. The density of dendritic spines in DG and CA 1 regions in the SD+Sevo group was slightly decreased, suggesting that the effects of sleep deprivation and inhalation anesthesia on cognitive function ultimately changed synaptic plasticity and thus affected long-term cognitive function.