Figure 9 Change in hippocampal dendritic spines after administration of the SIK3 inhibitor YKL-05-099The changes of bilateral hippocampal neural plasticity in each group were observed by Golgi staining. In the DG region, there was a statistically significant increase in dendritic spine density in the SD and Sevo groups compared to before inhibitor administration. The density of dendritic spines in DG and CA 1 regions in the SD+Sevo group was slightly decreased, suggesting that the effects of sleep deprivation and inhalation anesthesia on cognitive function ultimately changed synaptic plasticity and thus affected long-term cognitive function.