19 December 2021 : Hypothesis
Tissue-Engineered Skin Regenerative Units for Epidermal Keratinocytes Expansion and Wound Healing
Xinjian Zhang1CE, Wen Xu2EF*, Xinlei Hu3ADOI: 10.12659/MSM.932978
Med Sci Monit 2021; 27:e932978
Figure 1 Schematic diagram of construction the TESRUs: (A) First, autologous fibroblasts are loaded on a biodegradable macroporous microcarrier. (B) Second, autologous epidermal keratinocytes and melanocytes are incubated with the fibroblast-loaded microcarriers. (C) Autologous epidermal keratinocytes and autologous melanocytes are expanded in the fibroblast-loaded microcarriers, which are regarded as the smallest unit with complete full-thickness skin regeneration ability. (D) Multiple TESRUs are delivered to the wound surface to regenerate the full-thickness skin.