18 October 2021 : Laboratory Research
Salicylate Induced GABAAR Internalization by Dopamine D1-Like Receptors Involving Protein Kinase C (PKC) in Spiral Ganglion Neurons
Jiangyuan Qin1ABCDEF, Tingjia Wei1BCD, Huiying Chen1BCD, Xiaoyu Lin1BC, Danxue Qin1BC, Fangyu Wei1BC, Peiqiang Liu1BC, Wenhua Ye1BC, Jiping Su1ADG*DOI: 10.12659/MSM.933278
Med Sci Monit 2021; 27:e933278
Figure 6 One pathway by which dopamine D1-like receptors mediated the salicylate-induced GABAA receptor internalization was through the effect of PKC on spiral ganglion neurons. After SS increased the PKC-dependent phosphorylation at γ2 S327 by D1Rs, the internalization of GABAARs was increased through a clathrin/dynamin-dependent pathway, then the surface level of GABAARs was reduced, resulting in a weakened GABAAR-mediated response. PowerPoint 2020 (Microsoft, USA) was used for the creation of the figure.