Figure 1 Construction of co-expression modules using the WGCNA package in R. (A) Analysis of the scale-free fit index for various soft-thresholding powers (β). The red line represents the merging threshold. (B) Analysis of the mean connectivity for various soft-thresholding powers. (C) The cluster dendrogram of genes in GSE81622. (D) Interaction relationship analysis of coexpressed genes. (E) Hierarchical clustering of module hub genes that summarize the modules yielded in the clustering analysis. (F) Heatmap plot of the adjacencies in the hub gene network.