Activation of α7 Nicotinic Acetylcholine Receptor by its Selective Agonist Improved Learning and Memory of Amyloid Precursor Protein/Presenilin 1 (APP/PS1) Mice via the Nrf2/HO-1 Pathway

Kun Cao; Jie Xiang; Yang-Ting Dong; Yi Xu; Zhi-Zhong Guan

doi:10.12659/MSM.933978

04 January 2022 : Animal Research

Activation of α7 Nicotinic Acetylcholine Receptor by its Selective Agonist Improved Learning and Memory of Amyloid Precursor Protein/Presenilin 1 (APP/PS1) Mice via the Nrf2/HO-1 Pathway

Kun Cao^12BCEF, Jie Xiang^13CF, Yang-Ting Dong^34BCD, Yi Xu^13CD, Zhi-Zhong Guan^134ADG*

DOI: 10.12659/MSM.933978

Med Sci Monit 2022; 28:e933978

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Figure 2 Absence of any significant histopathological changes in different regions of the hippocampus of the APP/PS1 mice at 6 or 10 months of age. (A) the APP/PS1 mice at 6 months of age. (B) the APP/PS1 mice at 10 months of age. WT – wild-type; Hippo – hippocampus; CA1/3 – Cornu Ammonis area 1/3; DG – dentate gyrus. Magnification: Hippocampus, 40×; CA1, CA2, DG regions, 200×.

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Activation of α7 Nicotinic Acetylcholine Receptor by its Selective Agonist Improved Learning and Memory of Amyloid Precursor Protein/Presenilin 1 (APP/PS1) Mice via the Nrf2/HO-1 Pathway

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