Activation of α7 Nicotinic Acetylcholine Receptor by its Selective Agonist Improved Learning and Memory of Amyloid Precursor Protein/Presenilin 1 (APP/PS1) Mice via the Nrf2/HO-1 Pathway

Kun Cao; Jie Xiang; Yang-Ting Dong; Yi Xu; Zhi-Zhong Guan

doi:10.12659/MSM.933978

04 January 2022 : Animal Research

Activation of α7 Nicotinic Acetylcholine Receptor by its Selective Agonist Improved Learning and Memory of Amyloid Precursor Protein/Presenilin 1 (APP/PS1) Mice via the Nrf2/HO-1 Pathway

Kun Cao^12BCEF, Jie Xiang^13CF, Yang-Ting Dong^34BCD, Yi Xu^13CD, Zhi-Zhong Guan^134ADG*

DOI: 10.12659/MSM.933978

Med Sci Monit 2022; 28:e933978

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Figure 6 Western blot for Nrf2/HO-1 in the brains of APP/PS1 mice. (A, C) Nrf2 expression at 6 and 10 months of age. (B, D) HO-1 expression at 6 and 10 months of age. The values presented are means±SD of n=10 mice. * P<0.05 compared to the wild-type (WT) group; # P<0.05 compared to the APP/PS1 group, as determined by analysis of variance (ANOVA), followed by the Tukey HSD test.

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Activation of α7 Nicotinic Acetylcholine Receptor by its Selective Agonist Improved Learning and Memory of Amyloid Precursor Protein/Presenilin 1 (APP/PS1) Mice via the Nrf2/HO-1 Pathway

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