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30 October 2021: Database Analysis

Construction and Verification of a Hypoxia-Stemness-Based Gene Signature for Risk Stratification in Esophageal Cancer

Kang Tang 1BCDE , Yong Cheng 2AF , Qian Li 3AF*

DOI: 10.12659/MSM.934359

Med Sci Monit 2021; 27:e934359

Figure 5 Multi-omics study to investigate the clinical value of hypoxia-stemness risk classifier(A) Correlation of patient risk score with immune infiltration based on xCell algorithm. (B) CD8 expression in high- and low-risk groups. (C) CD274 (PD-L1) expression in high-risk and low-risk patients. (D–I) Comparison of common chemotherapeutic agents’ sensitivity in high- and low-risk groups of ESCA patients, including Metformin (D), Mitomycin (E), Gefitinib (F), Bexarotene (G), Dasatinib. (H), and Imatinib (I). The significance was assessed by the Wilcoxon test. (J) Mutation mapping of ESCA patients between high and low-risk esophageal cancer patients, genes with the top 30 mutation frequencies were represented.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750