Lotus Seedpod Proanthocyanidins Protect Against Light-Induced Retinal Damage via Antioxidative Stress, Anti-Apoptosis, and Neuroprotective Effects

Jianmei Wang; Tao Yu; Liuqing Sheng; Hui Zhang; Fei Chen; Jie Zhu; Mingxing Ding

doi:10.12659/MSM.935000

24 December 2021 : Animal Research

Lotus Seedpod Proanthocyanidins Protect Against Light-Induced Retinal Damage via Antioxidative Stress, Anti-Apoptosis, and Neuroprotective Effects

Jianmei Wang

^1ABG*, Tao Yu^2B, Liuqing Sheng

^1C, Hui Zhang^3D, Fei Chen^1A, Jie Zhu^1F, Mingxing Ding^4AE

DOI: 10.12659/MSM.935000

Med Sci Monit 2021; 27:e935000

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Figure 7 Treatment of LSPCs alleviated light exposure-induced cell apoptosis in retina. (A) Representative photos of western blotting for pro-Caspase-3, cleaved Caspase-3, p53, Bax as well as Bcl-2 proteins. (B) Quantification of the expressions of pro-Caspase-3, cleaved Caspase-3, p53, Bax, and Bcl-2 as well as Bcl-2/Bax ratio in retina from control, light-induced retinal damage model, low-, medium-, and high-dose LSPCs groups. ** P<0.01; **** P<0.0001. GraphPad Prism software (version 8.0.1; Graph Pad; San Diego, CA, USA) was used to create the pictures.

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Lotus Seedpod Proanthocyanidins Protect Against Light-Induced Retinal Damage via Antioxidative Stress, Anti-Apoptosis, and Neuroprotective Effects

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