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12 March 2022: Lab/In Vitro Research

Downregulated Expression of RIPOR3 Correlated with Immune Infiltrates Predicts Poor Prognosis in Oral Tongue Cancer

Kai Zhang 1BCDE , Junlong Da 1F , Xiaoyao Liu 1F , Xinpeng Liu 1F , Jianqun Wang 1F , Han Jin 1D , Ying Li 1D , Bin Zhang 12AG*

DOI: 10.12659/MSM.935055

Med Sci Monit 2022; 28:e935055

Figure 1 The differentiated expression of RIPOR3 and correlation with survival outcomes. (A) Differentiated expression of RIPOR3 in normal tongue tissue (n=13) and oral squamous cell carcinoma of the mobile tongue (OTSCC) (n=127) in the The Cancer Genome Atlas cohort (P<0.0001). (B) Paired heterogeneous analysis of RIPOR3 expression in normal and tumor samples derived from the same patient (P=0.002 by the Wilcoxon rank-sum test). (C–E) Kaplan-Meier survival analysis of the relationship between RIPOR3 mRNA expression and overall survival (P=0.003), progression-free interval (P=0.017) and disease-specific survival (P=0.005) in OTSCC cases.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750