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15 June 2022: Animal Study

Differential circRNA and mRNA Expression Profiling During Osteogenic Differentiation in Rat Bone Marrow Mesenchymal Stem Cells

Yuan Yao 1ABCDEFG* , Jialin Liu 1BDE* , Wenjing Zhang 2BC , Xiangzhen Han 1G , Huiyu He 1AD* , Xiaowei Ji 1DE

DOI: 10.12659/MSM.936761

Med Sci Monit 2022; 28:e936761

Figure 4 Statistics of sequencing results of circRNAs. (A) Box-whisker plot reflect the signal difference of circRNAs sequencing samples. (B) Box-whisker plot reflect the signal difference of mRNAs sequencing samples. (C) circRNAs gene structure distribution map. (D) The circRNAs identified compared with circRNAs in the known database. (A, C) The heat maps were constructed based on expression values of circRNAs and mRNAs detected by RNA-seq, respectively. The expression values from -2 to 2 were depicted in line with the color scale representing the intensity increased from green to red. Three osteogenic induced groups and 3 control groups were included, and each group included 3 samples. Each column represented 1 sample and each row indicated 1 transcript. (B, D) Filtered transcripts were in gray, transcripts with nonsignificant differences were in blue, and transcripts with significant differences were in red. The log 2 foldchange was displayed on the horizontal axis, and −log 10 (P value) was displayed on the vertical axis.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750