Bioinformatics Profiling and Experimental Validation of 4 Differentially-Expressed LIM Genes in the Course of Colorectal-Adenoma-Carcinoma

Ying He; Zongfu Pan; Qian Shi; Xilin Zhang; Weiyun Shen; Lixia Huo; Huihui Guo; Chengwu Tang; Yuhang Ling

doi:10.12659/MSM.937081

20 July 2022 : Clinical Research

Bioinformatics Profiling and Experimental Validation of 4 Differentially-Expressed LIM Genes in the Course of Colorectal-Adenoma-Carcinoma

Ying He^12ABEFG, Zongfu Pan^3ACE, Qian Shi^14B, Xilin Zhang^14B, Weiyun Shen^14D, Lixia Huo^14D, Huihui Guo^14D, Chengwu Tang^14FG*, Yuhang Ling^14ACE

DOI: 10.12659/MSM.937081

Med Sci Monit 2022; 28:e937081

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Figure 1 Identification of differentially-expressed LIM genes (DELGs) in the mucosa-adenoma-carcinoma course. (A) Expression levels of LIM family genes in paired mucosa, adenoma, and carcinoma samples from the GSE117606 dataset were drawn in a heatmap. (B) Common DELGs from adenoma vs mucosa, and tumor vs mucosa are presented in a Venn diagram. (C) Expression of DELGs in mucosa, different types of polyps, and tumors (R, version 3.5.1; TBtools, version0.665).

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Bioinformatics Profiling and Experimental Validation of 4 Differentially-Expressed LIM Genes in the Course of Colorectal-Adenoma-Carcinoma

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