Integrating Network Pharmacology, Molecular Docking, and Experimental Validation to Investigate the Mechanism of (-)-Guaiol Against Lung Adenocarcinoma

Yaoying Zeng; Yanbin Pan; Bo Zhang; Yingbin Luo; Jianhui Tian; Yuli Wang; Xudong Ju; Jianchun Wu; Yan Li

doi:10.12659/MSM.937131

25 July 2022 : Database Analysis

Integrating Network Pharmacology, Molecular Docking, and Experimental Validation to Investigate the Mechanism of (-)-Guaiol Against Lung Adenocarcinoma

Yaoying Zeng^1E, Yanbin Pan^1B, Bo Zhang^1C, Yingbin Luo^1D, Jianhui Tian^1AF, Yuli Wang^1CD, Xudong Ju^2BF, Jianchun Wu^1A*, Yan Li^1A

DOI: 10.12659/MSM.937131

Med Sci Monit 2022; 28:e937131

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Figure 4 (A) Venn diagram was used to summarize the co-expression genes of DEGs, WGCNA module genes, and (−)-Guaiol target genes. (B) The 23 hub genes were predicted by topological screening of the protein–protein interaction (PPI) network with screening 2 times. DC – degree; BC – betweenness.

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Integrating Network Pharmacology, Molecular Docking, and Experimental Validation to Investigate the Mechanism of (-)-Guaiol Against Lung Adenocarcinoma

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