25 July 2022 : Database Analysis
Integrating Network Pharmacology, Molecular Docking, and Experimental Validation to Investigate the Mechanism of (-)-Guaiol Against Lung Adenocarcinoma
Yaoying Zeng1E, Yanbin Pan1B, Bo Zhang1C, Yingbin Luo1D, Jianhui Tian1AF, Yuli Wang1CD, Xudong Ju2BF, Jianchun Wu1A*, Yan Li1ADOI: 10.12659/MSM.937131
Med Sci Monit 2022; 28:e937131
Figure 9 (A) Flow cytometry to detect the apoptosis rate in A549 and Calu-1 treated with different concentrations of (−)-Guaiol. (B) Fluorescence microscope was used to observe apoptosis in A549 and Calu-1 treated with different concentrations of (−)-Guaiol. (C) Western blot analysis was used to detect the protein expression of BAX and Bcl-2 in A549 treated with (−)-Guaiol (60 μM or 120 μM). The relative BAX and Bcl-2 levels from 3 independent experiments were statistically analyzed using ANOV A test in the quantitative analysis. * P<0.05, *** P<0.001 vs control.