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07 November 2022 : Database Analysis  

Mechanism of Progesterone in Treatment of Traumatic Brain Injury Based on Network Pharmacology and Molecular Docking Technology

Chen Zheng1ABCDEFG, Jian Gong1CEF, Lili Zang2CDEF, Daiying Song2BCDF, Xinyue Ran2CDF, Juncen Li2BCDE, Bo Jiang1DF, Jianli Xu1BC, Qihua Wu1ACDFG*

DOI: 10.12659/MSM.937564

Med Sci Monit 2022; 28:e937564

Figure 2 (A) The intersection target of progesterone target and traumatic brain injury target (created using Venny2.1.0 website). (B) PPI network of the intersection target of progesterone and traumatic brain injury (created using the STRING online database). (C) The main sub-networks (functional modules) in the target network, according to the figure. The node degree value sets the size of the node. The larger the node, the redder the color, indicating that the node is more important. Set the thickness of the edge according to the binding score. The thicker the edge, the stronger the PPI relationship (created using CytoScape 3.8.2 Software Mapping). (D) In the intersection target, the top 10 key target genes are calculated according to ECC. The larger the node, the redder the color, and the higher the ranking (created using CytoScape 3.8.2 Software Mapping).

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750