07 November 2022: Database Analysis
Mechanism of Progesterone in Treatment of Traumatic Brain Injury Based on Network Pharmacology and Molecular Docking Technology
Chen Zheng 1ABCDEFG , Jian Gong 1CEF , Lili Zang 2CDEF , Daiying Song 2BCDF , Xinyue Ran 2CDF , Juncen Li 2BCDE , Bo Jiang 1DF , Jianli Xu 1BC , Qihua Wu 1ACDFG*DOI: 10.12659/MSM.937564
Med Sci Monit 2022; 28:e937564
Figure 2 (A) The intersection target of progesterone target and traumatic brain injury target (created using Venny2.1.0 website). (B) PPI network of the intersection target of progesterone and traumatic brain injury (created using the STRING online database). (C) The main sub-networks (functional modules) in the target network, according to the figure. The node degree value sets the size of the node. The larger the node, the redder the color, indicating that the node is more important. Set the thickness of the edge according to the binding score. The thicker the edge, the stronger the PPI relationship (created using CytoScape 3.8.2 Software Mapping). (D) In the intersection target, the top 10 key target genes are calculated according to ECC. The larger the node, the redder the color, and the higher the ranking (created using CytoScape 3.8.2 Software Mapping).