Figure 2 During the observation period, the dynamics of leptin and fibroblast growth factor 21 (FGF-21) as compared with inflammation markers, interleukin 6 (IL-6), C-reactive protein (CRP)(A) Leptin increased acutely at t24h (P<0.0001) to decline at t7d (P=0.043) while normalizing at t3m. (B) FGF-21 was elevated at both t24h (P<0.0001) and t7d (P<0.0001) and normalized at t3m. (C) Markers of acute inflammation, including IL-6 (D) were elevated at t24h (P<0.0001), while (E) CRP remained elevated across all of the time points (P<0.0001) as compared to baseline. Leptin levels slightly varied by surgery type at the baseline level and dynamics after surgery. Figures were generated using Prism by Graph Pad Dotmatics version 9. * Two-tailed significance less than 0.05 when data compared to baseline.