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Figure 1 Differentially expressed proteins (DEPs) of PDAC network construction and Enrichment analysis of DEPs. (A) Protein–protein interaction (PPI) network of 378 DEPs, with top 21 proteins being shown in red (STRING, version 11.5, https://string-db.org/). (B) The top 21 proteins with the highest degree values were identified using CytoHubba (Cytoscape, version 3.9.1, https://cytoscape.org/). These proteins were ranked in descending degree order from red to orange to yellow. (C) The predicted association rank (from low to high) of the top 30 proteins in the PPI network (R software, version 4.1.2, USA).