Effect of Cefoperazone/Sulbactam on Blood Coagulation Function in Infected Emergency Department Patients and the Necessity of Vitamin K1 (VK1) Preventive Intervention: A Single-Center, Retrospective Analysis

Xupeng Shao; Yuanyuan Ren; Na Xie; Kailiang Fan; Haiyan Sun; Jiamin Lu; Jiuxiang Wei; Xincheng Tian

doi:10.12659/MSM.939203

05 June 2023 : Database Analysis

Effect of Cefoperazone/Sulbactam on Blood Coagulation Function in Infected Emergency Department Patients and the Necessity of Vitamin K1 (VK1) Preventive Intervention: A Single-Center, Retrospective Analysis

Xupeng Shao^1ABCDEFG, Yuanyuan Ren^1B, Na Xie^1BC, Kailiang Fan^1A*, Haiyan Sun^1EF, Jiamin Lu^2E, Jiuxiang Wei^2F, Xincheng Tian^2F

DOI: 10.12659/MSM.939203

Med Sci Monit 2023; 29:e939203

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Figure 5 After cefoperazone/sulbactam administration, the international normalized ratio (INR) increased significantly and prothrombin time (PT) and activated partial thrombin time (APTT) were prolonged, suggesting coagulation dysfunction. After treatment with vitamin K1, the INR decreased and PT and APTT were shortened, suggesting that coagulation function improved.

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Effect of Cefoperazone/Sulbactam on Blood Coagulation Function in Infected Emergency Department Patients and the Necessity of Vitamin K1 (VK1) Preventive Intervention: A Single-Center, Retrospective Analysis

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