Review of the Pathogenesis, Diagnosis, and Management of Osteoradionecrosis of the Femoral Head

Yang Li; Zhongsheng Zhou; Shenghao Xu; Jinlan Jiang; Jianlin Xiao

doi:10.12659/MSM.940264

13 June 2023: Review Articles

Review of the Pathogenesis, Diagnosis, and Management of Osteoradionecrosis of the Femoral Head

Yang Li ^12EF , Zhongsheng Zhou ^12BC , Shenghao Xu ^1B , Jinlan Jiang ^2A , Jianlin Xiao ^1AE*

DOI: 10.12659/MSM.940264

Med Sci Monit 2023; 29:e940264

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Background Hip Anatomy and Biomechanics Epidemiology Pathogenesis Diagnosis and Differential Diagnosis Treatment Future Directions Conclusions References

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Figure 1 The pathogenesis of osteoradionecrosis (ORN). Medical research and clinical experience with radiation-induced bone injury revealed that the pathogenesis of ORN includes bone loss, radiation-induced fibrosis, vascular injury, mesenchymal stem cell injury, reactive oxygen species, and cell senescence. SASP – senescence-associated secretory phenotype. Created with BioRender.com.

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Review of the Pathogenesis, Diagnosis, and Management of Osteoradionecrosis of the Femoral Head

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