02 July 2023 : Review article
Advancements in Zebrafish Models for Breast Cancer Research: Unveiling Biomarkers, Targeted Therapies, and Personalized Medicine
Anna Wawruszak
1ABCDEFG*, Estera Okoń 1ABCDEF, Karolina Dudziak 1ABCDEFG
DOI: 10.12659/MSM.940550
Med Sci Monit 2023; 29:e940550
Background
Zebrafish Breast Cancer In Vivo Models
Breast Cancer Patient-Derived Xenografts
Troubleshooting In Vivo Models
Epithelial-Mesenchymal Transition (EMT) in Tumor Metastasis
Modeling Breast Cancer Metastasis with Zebrafish
Importance of TGF-β in the Process of Metastasis
Role of PTEN in Invasion and Migration of Cancer Cells
Role of CXCR4-CXCL12 Chemokine Signaling Axis in Cancer Cell Migration
Metastatic Capacity of Circulating Tumor Cells
Study of Effect of the Microenvironment on Breast Cancer Cells
Zebrafish as a Preclinical Model for Drug Screening
Monoclonal Antibodies Studies in Zebrafish Model
Synthetic Drugs Studies in Zebrafish Model
Natural Products Studies in Zebrafish Model
Future Directions
Conclusions
References
Figure 2 The advantages of zebrafish (ZF) (Danio reiro) as a vertebrate preclinical animal model include low cost and ease of maintenance, short generation time, small size, intensive external development, transparent embryos, and convenient genetic manipulations and analysis. The figure was created with BioRender.com (Toronto, Canada) (accessed on 23 April 2023).