A Review of Preclinical and Clinical Studies in Support of the Role of Non-Steroidal Anti-Inflammatory Drugs in Dentistry

Anna Kotowska-Rodziewicz; Anna Zalewska; Mateusz Maciejczyk

doi:10.12659/MSM.940635

25 June 2023 : Review article

A Review of Preclinical and Clinical Studies in Support of the Role of Non-Steroidal Anti-Inflammatory Drugs in Dentistry

Anna Kotowska-Rodziewicz^1ABCDEFG, Anna Zalewska^1ABCDEF, Mateusz Maciejczyk

^2ABCDEFG*

DOI: 10.12659/MSM.940635

Med Sci Monit 2023; 29:e940635

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Background Pain in Dentistry Effects of NSAIDs on Cyclooxygenase NSAIDs in Dentistry Topical Use of NSAIDs in Dentistry Adverse Effects of NSAIDs Used in Dentistry Interactions of NSAIDs Future Directions Conclusions References

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Figure 3 Effects of NSAIDs on cyclooxygenaseCreated with BioRender.com. The mechanism of action of NSAIDs is connected with the inhibition of cyclooxygenase (COX), which blocks the conversion of arachidonic acid to proinflammatory prostaglandins. NSAIDs reduce inflammation and pain in periodontitis/mucositis or after oral surgery. Although COX exists in 2 isoforms (COX-1 and COX-2), COX-2 is responsible for proinflammatory effects, while COX-1 serve mainly physiological functions. Therefore, most NSAID adverse effects are associated with COX-1 inhibition including gastrointestinal damage, liver damage or cardiovascular complications.

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A Review of Preclinical and Clinical Studies in Support of the Role of Non-Steroidal Anti-Inflammatory Drugs in Dentistry

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