Figure 5 Image of cone mosaic in a patient with cone-rod dystrophyImage of cone mosaic in a patient with cone-rod dystrophy obtained with adaptive optics camera 4°×4° degree square (Rtx-1, Imagine Eyes, Orsay, France). The analysis was performed at superior 2° from the fovea. Empty spaces at the photoreceptor level and a disrupted mosaic of photoreceptors are demonstrated (top). The region of interest (ROI) (yellow square in the top image) was used for automated cone segmentation (bottom right) and detection (bottom left) using dedicated software. Red squares correspond to automatically identified cones (bottom right). Low density of the cones and the defect in the cones is demonstrated (bottom). The image is from the author’s collection.