15 June 2024 : Database Analysis
Comprehensive Analysis of Sphingolipid Metabolism-Related Genes in Osteoarthritic Diagnosis and Synovial Immune Dysregulation
Zheng Zhu1DE, Bizhi Tu1B, Run Fang1C, Jun Tong1D, Yulong Liu1F, Rende Ning1A*DOI: 10.12659/MSM.943369
Med Sci Monit 2024; 30:e943369
Figure 2 Differential expression of genes of the sphingolipid metabolism pathways (SMP). (A) Principal component analysis (PCA) plot shows the batch effect was removed among the 4 obtained datasets. (B) Upregulated expression of sphingolipid metabolism in OA synovium. (C) Volcano plot, box plot, and heat map of differentially expressed SMP genes between OA and healthy (CT) synovium. (D) The rank of SMP-related genes by the random forest analysis and SVM-RFE algorithm. * P<0.05. Drawn by AI (Adobe Illustrator CC2021, v25.0.0.60 for Mac version, Adobe Corporation) and R (version 4.2.1, JJ Allaire Company).