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15 June 2024 : Database Analysis  

Comprehensive Analysis of Sphingolipid Metabolism-Related Genes in Osteoarthritic Diagnosis and Synovial Immune Dysregulation

Zheng Zhu1DE, Bizhi Tu1B, Run Fang1C, Jun Tong1D, Yulong Liu1F, Rende Ning1A*

DOI: 10.12659/MSM.943369

Med Sci Monit 2024; 30:e943369

Figure 3 Prediction model for OA was constructed by identified hub genes related to sphingolipid metabolism. (A) Six candidate hub genes were identified by random forest and SVM-RFE analysis. (B) Nomogram of 6 candidate hub genes in the diagnosis of OA patients. (C) Receiver operating characteristic (ROC) curve and its verification of repeated sampling, as well as calibration curve indicates the excellence and robustness of model in predicting the OA occurrence. (D) Model evaluation curves: A diagnostic model containing multiple nominated hub genes makes patients more profitable than a single gene. * P<0.05, ** P<0.01. Drawn by AI (Adobe Illustrator CC2021, v25.0.0.60 for Mac version, Adobe Corporation) and R (version 4.2.1, JJ Allaire Company).

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750